5-AMINO-3-CHLOROPYRIDAZINE synthesis
- Product Name:5-AMINO-3-CHLOROPYRIDAZINE
- CAS Number:29049-45-4
- Molecular formula:C4H4ClN3
- Molecular Weight:129.55
1837-55-4
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29049-45-4
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$50.00/25 mg
Yield:29049-45-4 62%
Reaction Conditions:
with ammonia in 1,4-dioxane at 100;
Steps:
73.1 Step 1: Synthesis 6-chloropyridazin-4-amine:
Into a 25-mL round-bottom flask, was placed 3,5-dichloropyridazine (1 g, 6.71 mmol, 1 equiv), ammonia (8 mL), dioxane (2 mL). The resulting solution was stirred overnight at 100 °C. The solids were collected by filtration. This resulted in 570 mg (62%) of the title compound as a brown solid. Analytical Data: LC-MS: (ES, m/z): RT= 0.434 min, LCMS 53, m/z = 130 [M+l].
References:
EPIZYME, INC.;CAMPBELL, John Emmerson;DUNCAN, Kenneth William;FOLEY, Megan Alene;HARVEY, Darren Martin;KUNTZ, Kevin Wayne;MILLS, James Edward John;MUNCHHOF, Michael John WO2017/181177, 2017, A1 Location in patent:Paragraph 0941-0944
7440-44-0
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$12.00/25g
934-26-9
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inquiry
29049-45-4
154 suppliers
$50.00/25 mg