ChemicalBook CAS DataBase List 4-AMINOPYRIDAZINE

4-AMINOPYRIDAZINE synthesis

5synthesis methods

Product Name:4-AMINOPYRIDAZINE
CAS Number:20744-39-2
Molecular formula:C4H5N3
Molecular Weight:95.1

823-58-5 Synthesis

823-58-5
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$9.00/1g

20744-39-2
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$15.00/250mg

Yield:20744-39-2 100%

Reaction Conditions:

with sodium hydroxide;hydrogen;palladium 10% on activated carbon in tetrahydrofuran;water at 20; for 48 h;

Steps:

151.1

Example 151; 4-(3-Phenyl-1,2,4-thiadiazol-5-yl)-N-pyridazin-4-ylpiperazine-1-carboxamide; (1) Pyridazine-4-amine; A mixture of 3,6-dichloropyridazine-4-amine (5.00 g, 18.2 mmol), tetrahydrofuran (100 ml), sodium hydroxide (8.00 g, 200 mmol), water (32 ml) and 10% palladium-carbon (500 mg) was stirred under a hydrogen atmosphere at room temperature for 2 days, insolubles were filtered off and the filtrate was concentrated. The residue was dissolved in methanol (100 ml), insolubles were filtered off and the filtrate was concentrated to obtain the desired product quantitatively as a solid. ¹H-NMR (DMSO-d₆) δ; 2.51 (2H, br s), 6.00 (1H, br s), 7.81 - 7.85 (1H, m), 7.98 - 8.00 (1H, m).

References:

EP1813606,2007,A1 Location in patent:Page/Page column 83-84