5-AMINO-4-CHLOROPYRIMIDINE synthesis
- Product Name:5-AMINO-4-CHLOROPYRIMIDINE
- CAS Number:54660-78-5
- Molecular formula:C4H4ClN3
- Molecular Weight:129.55
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Yield: 47%
Reaction Conditions:
with ammonia;water;nickel in ethanol at 20 - 80;
Steps:
19
To the product of Example 18 (4.3 g, 26 mmol) dissolved in conc. NH4OH (4 mL) was added EtOH (40 mL). To this solution, Raney Nickel (excess) was added in portions. The reaction was stirred at room temperature overnight and then heated at 80° C. for 2 hrs. The mixture was filtered through Celite and the filtrate concentrated. The crude product was purified by flash chromatography on silica using EtOAc/hexanes to afford 1.6 g (47%) of the title compound as a yellow solid.
References:
Elan Pharmaceutical Inc. US2006/13799, 2006, A1 Location in patent:Page/Page column 59
54851-35-3
33 suppliers
inquiry
54660-78-5
148 suppliers
$13.00/100mg