5-Amino-8-quinolinol dihydrochloride synthesis
- Product Name:5-Amino-8-quinolinol dihydrochloride
- CAS Number:21302-43-2
- Molecular formula:C9H10Cl2N2O
- Molecular Weight:233.09
63450-86-2
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21302-43-2
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Yield: 69%
Reaction Conditions:
Stage #1:5-Nitroso-8-hydroxyquinoline hydrochloride with sodium hydroxide;sodium dithionite in water at 75 - 80;
Stage #2: with hydrogenchloride;water at 50;
Steps:
2 EXAMPLE 2, 5amino-8-hydroxyquinoline dihydrochloride
EXAMPLE 2 5amino-8-hydroxyquinoline dihydrochloride 5-nitroso-8-hydroxyquinoline chloride (40 g) was added to a mixture of water (160 ml) and 5N-NaOH (260 ml) and heated to 40° C. Na2S2O4 (95 g) was added to the reaction mixture wraith increasing temperature to 75-80° C. The reaction mixture was cooled to 50° C. and 12N-HCl (250 ml) was added to it. Then the reaction mixture was cooled to 0° C. and filtered to give 5-amino-8-hydroxyquinoline dihydrochloride (34 g, 69%).
References:
Il Jin Copper Foil Corp. US6818653, 2004, B1 Location in patent:Page column 5
4008-48-4
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21302-43-2
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21302-43-2
116 suppliers
$40.00/1g