5-Benzyl-6-methyl-1H-pyrimidine-2,4-dione synthesis

6synthesis methods

Product Name:5-Benzyl-6-methyl-1H-pyrimidine-2,4-dione
CAS Number:428444-70-6
Molecular formula:C12H12N2O2
Molecular Weight:216.24

620-79-1
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57-13-6 Synthesis

57-13-6
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5-Benzyl-6-methyl-1H-pyrimidine-2,4-dione

428444-70-6
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Yield:428444-70-6 75%

Reaction Conditions:

with boron trifluoride diethyl etherate at 145; for 0.15 h;Neat (no solvent);Microwave irradiation;

Steps:

Synthesis using BF₃ (6, same procedure applied for compound 7, 8, and 10)

General procedure: Ethyl 3-oxo-3-phenylpropanoate (384mg, 2mmol) taken in a reactor vessel with BF₃Et₂O (339mg, 2.4mmol) was mixed thoroughly for 1 min with urea (156 mg, 2.6mmol). The vessel was closed immediately and was subjected to microwave irradiation for about 4 min at about 145°C. The compound (6) was further purified by column chromatography. Yeild: 92%

References:

Burgula, Laxmi Narayana;Radhakrishnan;Kundu, Lal Mohan [Tetrahedron Letters,2012,vol. 53,# 21,p. 2639 - 2642] Location in patent:supporting information; experimental part

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918631-04-6
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362690-43-5 Synthesis

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918631-01-3 Synthesis

1,3-dibenzyl-5-((benzyloxy)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione

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428444-70-6
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626-48-2 Synthesis

626-48-2
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428444-70-6
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References