5-broMo-1,2-diphenyl-1H-benzo[d]iMidazole synthesis

11synthesis methods

Product Name:5-broMo-1,2-diphenyl-1H-benzo[d]iMidazole
CAS Number:760212-55-3
Molecular formula:C19H13BrN2
Molecular Weight:349.22

68765-53-7 Synthesis

68765-53-7
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100-52-7 Synthesis

100-52-7
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5-broMo-1,2-diphenyl-1H-benzo[d]iMidazole

760212-55-3
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Yield:760212-55-3 72%

Reaction Conditions:

with sodium metabisulfite;calcium hydride in N,N-dimethyl-formamide at 130; for 16 h;

Steps:

compound 9 (10.2 g, 38.9 mmol),Benzaldehyde (4.5 mM, 42.8 mmol),Sodium metabisulfite (7.45 g, 39.3 mmol),Dimethylformamide (DMF, 200 ml), which is dehydrated with calcium hydride (CaH2),At 130 ° for 16 hours, the temperature was lowered to room temperature, and the solution was dropped into water.The brown solid was filtered, washed with diethyl ether, ethanol and ethyl acetate.Recrystallization from dichloromethane/ethanol gave 9.4 g of a pale yellow solid.The yield was 72%.

References:

CN109516980,2019,A Location in patent:Paragraph 0039