5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE synthesis
- Product Name:5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE
- CAS Number:463336-07-4
- Molecular formula:C11H7BrFN
- Molecular Weight:252.08
624-28-2
715 suppliers
$5.00/5g
1765-93-1
551 suppliers
$9.00/1g
463336-07-4
31 suppliers
$55.00/25mg
Yield:463336-07-4 90%
Reaction Conditions:
with palladium diacetate;potassium carbonate;triphenylphosphine in methanol;acetonitrile at 50; for 24 h;Inert atmosphere;regioselective reaction;Suzuki Coupling;
Steps:
Typical procedure for the 2-arylation of 2,5- and 2,3-dibromopyridines
General procedure: 2,5-dibromopyridine (0.12 g, 0.50 mmol), phenylboronic acid (67 mg, 0.55 mmol), K2CO3 (0.14 g, 1.0 mmol), Pd(OAc)2 (11 mg, 5 mol %), PPh3 (26 mg, 10 mol %) were dissolved in CH3CN/CH3OH (2:1, 6 mL). The solution was stirred at 50 °C under nitrogen atmosphere for 24 h and then cooled and the solid was filtered off. The filtrate was then concentrated and the resulting crude product was dissolved in CH2Cl2 (10 mL). The solution was washed with water (10 mL*3) and brine (10 mL), and dried over sodium sulfate. Upon removal of the solvent with a rotavapor, the resulting residue was subjected to column chromatography (petroleum ether/AcOEt, 400:1) to give the desired product 3a (114 mg, 97%) as a white solid.
References:
Zhou, Qizhong;Zhang, Bin;Su, Liangjun;Jiang, Tiansheng;Chen, Rener;Du, Tieqi;Ye, Yuyuan;Shen, Jianfen;Dai, Guoliang;Han, Deman;Jiang, Huajiang [Tetrahedron,2013,vol. 69,# 51,p. 10996 - 11003]
223463-13-6
369 suppliers
$5.00/1g
1765-93-1
551 suppliers
$9.00/1g
463336-07-4
31 suppliers
$55.00/25mg
624-28-2
715 suppliers
$5.00/5g
437-29-6
2 suppliers
$172.00/25MG
463336-07-4
31 suppliers
$55.00/25mg