ChemicalBook CAS DataBase List 5-Bromo-2-methoxypyridine

5-Bromo-2-methoxypyridine synthesis

14synthesis methods

Product Name:5-Bromo-2-methoxypyridine
CAS Number:13472-85-0
Molecular formula:C6H6BrNO
Molecular Weight:188.02

5-Bromo-2-methoxypyridine is used as a ligand for central nicotinic acetylcholine receptor. It was prepared from 2,5-dibromopyridine with sodium hydroxide by stirring in methanol refluxed for 5 h.

624-28-2 Synthesis

624-28-2
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67-56-1 Synthesis

67-56-1
740 suppliers
$7.29/5ml-f

13472-85-0
508 suppliers
$8.00/1g

Yield:13472-85-0 98%

Reaction Conditions:

with sodium hydroxide for 5 h;Reflux;

Steps:

3.1, 1Br Example 3
(1) In a 500 ml reaction flask, 47 g of 2,5-dibromopyridine,8 g of solid sodium hydroxide and 200 ml of methanol,Stirring began to heat up to reflux, the reaction time was 5 hours,Stop the reaction, steamed most of the methanol, cooled, add 100 ml of water,Extract once with dichloromethane, remove methylene chloride to give the crude product,The crude product was distilled under reduced pressure to give 2-methoxy-5-bromopyridine,The yield is 98%.

References:

Huaihua Jinxin New Materials Co., Ltd.;Wang Youming CN106905229, 2017, A Location in patent:Paragraph 0026; 0027

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624-28-2 Synthesis

624-28-2
712 suppliers
$5.00/5g

13472-85-0
508 suppliers
$8.00/1g

References

624-28-2 Synthesis

624-28-2
712 suppliers
$5.00/5g

124-41-4 Synthesis