ChemicalBook CAS DataBase List 5-BROMO-2-(METHYLAMINO)PYRIMIDINE

5-BROMO-2-(METHYLAMINO)PYRIMIDINE synthesis

4synthesis methods

Product Name:5-BROMO-2-(METHYLAMINO)PYRIMIDINE
CAS Number:31402-54-7
Molecular formula:C5H6BrN3
Molecular Weight:188.03

32779-36-5 Synthesis

32779-36-5
630 suppliers
$5.00/5g

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

31402-54-7
117 suppliers
$5.00/100mg

Yield: 100%

Reaction Conditions:

in methanol;water for 72 h;Reflux;

Steps:

18.1
40% Aqueous methylamine solution (35 ml) and methanol (20 ml) were added to 5-bromo-2-chloropyrimidine (3 g, 15.5 mmol) and the resulting mixture was heated to reflux for 3 days. The mixture was cooled, then the solvent was evaporated under reduced pressure, the residue was partitioned with methylene chloride and 1 M sodium hydroxide, the organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.0 g, 100%) as a white solid.¹H-NMR (CDCl₃) δ: 2.98 (3H, d, J=5.12 Hz), 5.16 (1H, brs), 8.29 (2H, s).

References:

DAIICHI SANKYO COMPANY, LIMITED US2010/130492, 2010, A1 Location in patent:Page/Page column 93

7752-82-1 Synthesis