5-bromo-2-phenylpyrimidin-4-ol synthesis
- Product Name:5-bromo-2-phenylpyrimidin-4-ol
- CAS Number:26786-28-7
- Molecular formula:C10H7BrN2O
- Molecular Weight:251.08
33643-94-6
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26786-28-7
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Yield:26786-28-7 76%
Reaction Conditions:
with N-Bromosuccinimide;acetic acid at 60; for 1 h;
Steps:
1
To a stirring solution of 21 (100 mg, 0. 58 mmol) and acetic acid (2.0 ml) in a 50 mL three-necked round-bottomed flask equipped with a magnetic stirrer and reflux condenser, was added N-BROMOSUCCINIMIDE (103 mg, 0.58 mmol). The mixture was heated at 60 °C for 1 hour. The solution was concentrated under reduced pressure and the residue was purified by silica gel chromatography using (97% CH2CL2, 3% MEOH) to obtain 24 (110 mg, 0.44 mmol, 76% yield) as a white SOLID. LH NMR (DMSO-D6) 8 7. 44-7. 61 (m, 3H), 8. 04-8.16 (m, 2H), 8.44 (s, 1H) 13.23 (s, 1H); M+1 (obs) = 251. 1; Rt = 2.98.
References:
WO2005/3099,2005,A2 Location in patent:Page 131
81560-03-4
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960-16-7
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$30.98/1g
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