5-BroMo-2-(piperidin-1-yl)benzonitrile synthesis

4synthesis methods

Product Name:5-BroMo-2-(piperidin-1-yl)benzonitrile
CAS Number:876918-30-8
Molecular formula:C12H13BrN2
Molecular Weight:265.149

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Yield:876918-30-8 97%

Reaction Conditions:

Stage #1: 5-Bromo-2-fluoro-benzonitrilewith potassium carbonate in N,N-dimethyl-formamide at 20; for 1 h;
Stage #2: piperidine in N,N-dimethyl-formamide at 80; for 3 h;

Steps:

12.1 Synthesis of 1-(3-cyano-4-piperidinephenyl)imidazole-4-carboxylic acid (A12)

(1) 5-bromo-2-fluorobenzonitrile (1.0 g, 5.0 mmol) was weighed and dissolved in DMF (10 mL), K2CO3 (2.1 g, 15.0 mmol) was added and stirred at room temperature for 1.0 h. Piperidine (1.3 g, 15.0 mmol) was added and the reaction was carried out at 80 ° C for 3 h.TLC followed the reaction completely.Cooled to room temperature, diluted with 100 mL of water, ethyl acetate (100mL × 3). The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure,Purified by silica gel column (V ethyl acetate: V petroleum ether = 1:20) to give 5-bromo-2-piperidine-benzonitrile (a12)1.29 g, yield 97%

References:

CN110078668,2019,A Location in patent:Paragraph 0142-0144

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References

Oxazole, 2-(5-bromo-2-methoxyphenyl)-4,5-dihydro-4,4-dimethyl-

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References