5-Bromo-3-nitropyridine-2-carbonitrile synthesis
- Product Name:5-Bromo-3-nitropyridine-2-carbonitrile
- CAS Number:573675-25-9
- Molecular formula:C6H2BrN3O2
- Molecular Weight:228
15862-37-0
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544-92-3
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573675-25-9
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$13.00/5g
Yield:573675-25-9 59%
Reaction Conditions:
at 150; for 2 h;
Steps:
10.2
(2) Production of 5-bromo-2-cyano-3-nitropyridine: 2,5-Dibromo-3-nitropyridine (3.80 g, 13.4 mmol) and copper cyanide (2.42 g, 26.8 mmol) were mixed, and stirred under heat at 150°C for 2 hours. After cooled to room temperature, the contents were filtered, and the residue was washed with acetone. The mother liquid was concentrated, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate = 9/1 to 3/1) to obtain the intended compound (1.80 g, 59 %) as a yellow solid.
References:
BANYU PHARMACEUTICAL CO., LTD. EP1757594, 2007, A1 Location in patent:Page/Page column 76
15862-34-7
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573675-25-9
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$13.00/5g
6945-68-2
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$9.00/5g
573675-25-9
279 suppliers
$13.00/5g