ChemicalBook CAS DataBase List (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

(5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone synthesis

3synthesis methods

Product Name:(5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone
CAS Number:742085-70-7
Molecular formula:C10H11BrN2O
Molecular Weight:255.11

123-75-1 Synthesis

123-75-1
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$10.00/5g

30766-11-1 Synthesis

30766-11-1
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$3.00/1g

(5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

742085-70-7
32 suppliers
$55.00/250mg

Yield:742085-70-7 68%

Reaction Conditions:

Stage #1: 5-bromo-2-pyridinecarboxylic acidwith 1,1′-carbonyldiimidazole in dichloromethane at 20; for 0.25 h;sarstedt tube;
Stage #2: tetrahydropyrrole in dichloromethane; for 1 h;

Steps:

1

A solution of δ-bromopyridine^-carboxylic acid (210mg, 1.04mmol) in dichloromethane (4ml) was treated with 1 ,1 '-carbonyldiimidazole (169mg, 1.04mmol) in one portion at room temperature. This mixture was shaken in a 15ml sarstedt tube for 15 minutes. Pyrrolidine (74mg, 1.04mmol) was then added in one portion and shaking continued for 1 hour. Saturated sodium hydrogen carbonate (3ml) solution was then added and the mixture shaken. The organic layer was removed, dried over sodium sulphate and evaporated under reduced pressure to give the title compound (181 mg, 68%).LC/MS (ES): Found 255 & 257 (ES+), retention time 2.13mins. Ci₀H₁₁BrN₂O requires 254 & 256.

References:

WO2008/110566,2008,A1 Location in patent:Page/Page column 29

123-75-1 Synthesis

123-75-1
535 suppliers
$10.00/5g

624-28-2 Synthesis