ChemicalBook CAS DataBase List 5-Bromo-2-pyridinecarboxylic Acid

5-Bromo-2-pyridinecarboxylic Acid synthesis

14synthesis methods

Product Name:5-Bromo-2-pyridinecarboxylic Acid
CAS Number:30766-11-1
Molecular formula:C6H4BrNO2
Molecular Weight:202.01

5-Bromo-2-pyridinecarboxylic acid is an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory organic synthesis process and chemical and pharmaceutical research and development process. 5-Bromo-2-pyridinecarboxylic acid can be synthesised by that Water and 5-bromo-2-methylpyridine was stirred at 80 °C, then KMnO4 (24.8 g, 157 mmol) was added in the mixtrue and stirred at the same temperature for 3-4 h. The reaction solution was filtered and purified to obtain light yellow solid, the final product.

29682-15-3 Synthesis

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

29682-15-3
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$8.00/1g

30766-11-1
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$3.00/1g

Yield:30766-11-1 90%

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran at 0 - 20; for 15 h;

Steps:

4.2.4. General synthetic procedure for compounds FA, 5a-m and 20
General procedure: Ester (FAE, 4a-m, 2a or 2b) (500 mg scale, 1 equiv.) was dissolvedin 6 ml THF at 0 °C in a 25 ml round-bottom flask. ThenNaOH(aq) (5 equiv.) was added dropwise and stirred for 15 h atroom temperature. After starting materials were consumed (byTLC), water (20 ml) was added. The reaction mixture was washedwith ethyl acetate (2 x 20 ml). The aqueous solution was acidified(pH 2-3) with 1 M HCl(aq) causing precipitation of a solid, whichwas filtered and dried under vacuum. Recrystallization in ethanolafford clean compound.

References:

Tung, Truong Thanh;Jakobsen, Tim Holm;Dao, Trong Tuan;Fuglsang, Anja Thoe;Givskov, Michael;Christensen, Søren Brøgger;Nielsen, John [European Journal of Medicinal Chemistry,2017,vol. 126,p. 1011 - 1020] Location in patent:supporting information

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3430-13-5 Synthesis