![](/CAS/20180808/GIF/30766-11-1.gif)
5-Bromo-2-pyridinecarboxylic Acid synthesis
- Product Name:5-Bromo-2-pyridinecarboxylic Acid
- CAS Number:30766-11-1
- Molecular formula:C6H4BrNO2
- Molecular Weight:202.01
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
269 suppliers
$8.00/1g
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
396 suppliers
$3.00/1g
Yield:30766-11-1 90%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran at 0 - 20; for 15 h;
Steps:
4.2.4. General synthetic procedure for compounds FA, 5a-m and 20
General procedure: Ester (FAE, 4a-m, 2a or 2b) (500 mg scale, 1 equiv.) was dissolvedin 6 ml THF at 0 °C in a 25 ml round-bottom flask. ThenNaOH(aq) (5 equiv.) was added dropwise and stirred for 15 h atroom temperature. After starting materials were consumed (byTLC), water (20 ml) was added. The reaction mixture was washedwith ethyl acetate (2 x 20 ml). The aqueous solution was acidified(pH 2-3) with 1 M HCl(aq) causing precipitation of a solid, whichwas filtered and dried under vacuum. Recrystallization in ethanolafford clean compound.
References:
Tung, Truong Thanh;Jakobsen, Tim Holm;Dao, Trong Tuan;Fuglsang, Anja Thoe;Givskov, Michael;Christensen, Søren Brøgger;Nielsen, John [European Journal of Medicinal Chemistry,2017,vol. 126,p. 1011 - 1020] Location in patent:supporting information
![5-Bromo-2-methylpyridine](/CAS/GIF/3430-13-5.gif)
3430-13-5
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$5.00/5g
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
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$3.00/1g
![2,5-Dibromopyridine](/CAS/GIF/624-28-2.gif)
624-28-2
712 suppliers
$5.00/5g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
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$175.00/23402
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
396 suppliers
$3.00/1g
![5-Bromopyridine-2-carbaldehyde](/CAS/GIF/31181-90-5.gif)
31181-90-5
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$5.00/250mg
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
396 suppliers
$3.00/1g
![5-Bromo-2-pyridinecarbonitrile](/CAS/20180808/GIF/97483-77-7.gif)
97483-77-7
550 suppliers
$10.00/5g
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
396 suppliers
$3.00/1g