![](/CAS/GIF/29682-15-3.gif)
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- CAS Number:29682-15-3
- Molecular formula:C7H6BrNO2
- Molecular Weight:216.03
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
397 suppliers
$3.00/1g
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
272 suppliers
$8.00/1g
Yield:29682-15-3 92%
Reaction Conditions:
with sulfuric acid at 0 - 70; for 6 h;
Steps:
12 Synthesis of methyl 5-bromopicolinate (12.5).
To a solution of 5-bromopicolinic acid (12.6, 6.0 g, 29.9 mmol) in methanol (60 mL), sulfuric acid (3.0 mL) was added at 0 °C and the reaction mixture was heated at 70 °C for 6 h. After completion, cooled the mixture to room temperature and methanol was removed under reduced pressure. To the mixture, water (50 mL) was added and pH was adjusted to 6 by a solution of sodium bicarbonate .The product was extracted with ethyl acetate (200 mL), the organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product was purified by washings with diethyl ether and pentane to afford methyl 5-bromopicolinate (12.5) as white solid. Yield: 6.0 g, 92.0%.
References:
ADHAERE PHARMACEUTICALS, INC.;BARBOSA, Antonio J. WO2018/126072, 2018, A1 Location in patent:Paragraph 0246; 0247
![2,5-Dibromopyridine](/CAS/GIF/624-28-2.gif)
624-28-2
712 suppliers
$5.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
201230-82-2
1 suppliers
inquiry
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
272 suppliers
$8.00/1g
![5-Bromo-2-pyridinecarboxylic Acid](/CAS/20180808/GIF/30766-11-1.gif)
30766-11-1
397 suppliers
$3.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
208 suppliers
$33.00/5g
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
272 suppliers
$8.00/1g
![2,5-Dibromopyridine](/CAS/GIF/624-28-2.gif)
624-28-2
712 suppliers
$5.00/5g
![Methyl formate](/CAS/20180808/GIF/107-31-3.gif)
107-31-3
328 suppliers
$16.00/25mL
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
272 suppliers
$8.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
201230-82-2
1 suppliers
inquiry
![5-Bromo-2-iodopyridine](/CAS/GIF/223463-13-6.gif)
223463-13-6
369 suppliers
$5.00/1g
![5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/29682-15-3.gif)
29682-15-3
272 suppliers
$8.00/1g