ChemicalBook CAS DataBase List 5-CHLORBENZOFURAZAN-3-OXIDE

5-CHLORBENZOFURAZAN-3-OXIDE synthesis

6synthesis methods

Product Name:5-CHLORBENZOFURAZAN-3-OXIDE
CAS Number:39060-31-6
Molecular formula:C6H3ClN2O2
Molecular Weight:170.55

345-18-6 Synthesis

345-18-6
192 suppliers
$7.00/5g

39060-31-6
14 suppliers
$82.70/5g

Yield:39060-31-6 34%

Reaction Conditions:

with sodium azide in water;N,N-dimethyl-formamide at 120; for 5 h;Reagent/catalyst;

Steps:

Methodology for preparation of benzofuroxans

General procedure: Method a. A solution of commercial o-halonitrobenzene (1 mmol) and sodium azide (1 mmol) in DMF (2.5 mL) and H₂O (0.5 mL) was prepared. It was refluxed at 120 °C for several minutes with evolution of N₂ gas. When this evolution was stopped, the reaction mixture was poured into an ice/water mixture to induce precipitation of product. The solid was removed by filtration. It was purified by column chromatography with silica gel and chloroform. In some cases, a crystalline benzofuroxan was obtained and it was only recrystallized in ethanol. All the products were characterized by UV-Vis, IR, ¹H NMR and HRMS.

References:

Leyva, Elisa;Leyva-Ramos, Socorro;Jiménez-Cata?o, Rogelio;de Luna-Méndez, Telma A.;Cárdenas-Chaparro, Agobardo [Synthetic Communications,2017,vol. 47,# 6,p. 604 - 608] Location in patent:supporting information

89-61-2 Synthesis