ChemicalBook CAS DataBase List 5-CHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLIC ACID

5-CHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLIC ACID synthesis

6synthesis methods

Product Name:5-CHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLIC ACID
CAS Number:59908-47-3
Molecular formula:C10H8ClNO2
Molecular Weight:209.63

methyl 5-chloro-1-methyl-1H-indole-2-carboxylate

148356-79-0
12 suppliers
$90.00/50mg

5-CHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLIC ACID

59908-47-3
74 suppliers
$45.00/10mg

Yield:59908-47-3 94%

Reaction Conditions:

with sodium hydroxide in ethanol at 50; for 0.5 h;

Steps:

1.2 Preparation of 5-chloro-1-methyl-1H-indole-2-carboxylic acid

77 mg (0.34 mmol) of the compound prepared in the above step 1 was dissolved in ethanol, 2M sodium hydroxide was added, and the mixture was stirred at 50 ° C for 30 minutes. After completion of the reaction, the reaction mixture was extracted with 50 ml of ethyl acetate, washed with 4N hydrochloric acid and water, and dried over anhydrous sodium sulfate.And concentrated under reduced pressure to obtain 67 mg (0.32 mmol) of the title compound as white solid in 94% yield.

References:

KR101725451,2017,B1 Location in patent:Paragraph 0294; 0301-0303

4792-67-0 Synthesis