5-chloro-3-ethynylpyridin-2-amine synthesis
- Product Name:5-chloro-3-ethynylpyridin-2-amine
- CAS Number:866318-88-9
- Molecular formula:C7H5ClN2
- Molecular Weight:152.58
866318-90-3
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$45.00/10mg
866318-88-9
21 suppliers
$232.00/250mg
Yield:866318-88-9 92%
Reaction Conditions:
Stage #1: 2-amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyridinewith potassium tert-butylate in ethanol at 20 - 30;
Stage #2: with acetic acid in water;
Steps:
7.2 Step two:
Dissolve potassium tert-butoxide (0.2g) in ethanol (20.0g), control the temperature at 20-30°C, add compound 6 (20.0g) in batches, and keep the reaction until HPLC detects the raw material (compound 2). Less than 0.5%, add acetic acid (0.2g) and water (60.0g), filter and dryCompound 7 (12.5 g, yield 92.0%) was obtained.
References:
CN112574218,2021,A Location in patent:Paragraph 0124; 0129-0131
1072-98-6
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$5.00/1g
866318-88-9
21 suppliers
$232.00/250mg
211308-81-5
160 suppliers
$16.00/1g
866318-88-9
21 suppliers
$232.00/250mg
26163-03-1
316 suppliers
$6.00/5g
866318-88-9
21 suppliers
$232.00/250mg