5-cyclopropyl-2-phenylpyridine synthesis
- Product Name:5-cyclopropyl-2-phenylpyridine
- CAS Number:1245645-30-0
- Molecular formula:C14H13N
- Molecular Weight:195.26
27012-25-5
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Yield:1245645-30-0 86%
Reaction Conditions:
with potassium phosphate tribasic heptahydrate;C45H53ClFeNO2PPd in water;toluene at 100; for 4.5 h;Inert atmosphere;Suzuki coupling;
Steps:
4.2. General experimental procedure
General procedure: Potassium phosphate (0.75 mmol) and IIe (1 mol %) was added to the solution of aryl halides (0.25 mmol) and cyclopropylboronic acid (0.5 mmol) in toluene (2.0 mL) and water (100 μL). The mixture was heated to 100 °C for a proper time under nitrogen atmosphere and cooled to room temperature. Water (10 mL) was added and the mixture was extracted with EtOAc (3×15 mL), evaporated and purified by chromatography on silica gel.
References:
Zhang, Min;Cui, Xiuling;Chen, Xiaopei;Wang, Lianhui;Li, Jingya;Wu, Yusheng;Hou, Lifen;Wu, Yangjie [Tetrahedron,2012,vol. 68,# 3,p. 900 - 905] Location in patent:experimental part