5-cyclopropyl-2-thiophenecarboxaldehyde synthesis
- Product Name:5-cyclopropyl-2-thiophenecarboxaldehyde
- CAS Number:29481-26-3
- Molecular formula:C8H8OS
- Molecular Weight:152.21
Yield:29481-26-3 95%
Reaction Conditions:
with palladium diacetate;caesium carbonate;catacxium A in water;toluene at 100; for 16 h;Inert atmosphere;
Steps:
33.1 Step 1
A solution of 2a (25 g, 130 mmol), 2b (34 g, 390 mmol), Pd(OAc)2 (1.7 g, 7.6 mmol), cataCXium A (4.6 g, 13 mmol) and Cs2C03 (127 g, 390 mmol) in toluene/H20 (660 mL, toluene/H20 = 10/1) was stirred at 100°C for 16 hours under N2 atmosphere. The solution was extracted with EtOAc. The combined organic extracts were dried over Na2S04, purified using Si02 chromatography, eluting with petroleum ether: ethyl acetate (50: 1) to provide 2c (18.5 g, 95% yield). 1H MR (CDC13) δ: 9.78 (s, 1 H), 7.58 (d, J= 3.91 Hz, 1 H), 6.86 (d, J= 3.52 Hz, 1 H), 2.12 - 2.22 (m, 1 H), 1.10 - 1.19 (m, 2 H), 0.78 - 0.90 (m, 2 H)
References:
WO2014/110688,2014,A1 Location in patent:Page/Page column 80
7283-96-7
269 suppliers
$8.00/5g
1065010-87-8
151 suppliers
$6.00/250mg
29481-26-3
14 suppliers
inquiry