5-cyclopropylnicotinonitrile synthesis
- Product Name:5-cyclopropylnicotinonitrile
- CAS Number:900802-81-5
- Molecular formula:C9H8N2
- Molecular Weight:144.17
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Yield:900802-81-5 58%
Reaction Conditions:
with dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;potassium phosphate;palladium diacetate in tetrahydrofuran; for 16 h;Inert atmosphere;Reflux;
Steps:
1 Step 1 : 5-Cyclopropylnicotinonitrile
Step 1 : 5-Cyclopropylnicotinonitrile To a solution of 3-bromo-5-cyanopyridine (1 g, 5.3 mmol) in tetrahydrofuran was added cyclopropyl boronic acid (0.5 g, 5.6 mmol) and potassium phosphate (1.08 g, 15.9 mmol). The resulting solution was degassed with nitrogen for 10 minutes and then palladium (II) acetate and S-phos were added. The reaction mixture was refluxed for 16 h. The reaction mixture was diluted with water, extracted with ethyl acetate and concentrated under reduced pressure. The crude material was purified via column chromatography to afford 5-cyclopropylnicotinonitrile (0.45 g, 58%). MS (ES+) (M+H) 145.1774..
References:
WO2013/150416,2013,A1 Location in patent:Page/Page column 99
35590-37-5
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23719-80-4
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900802-81-5
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35590-37-5
225 suppliers
$6.00/250mg
1065010-87-8
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$6.00/250mg
900802-81-5
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