5-Ethyl-2-methoxy-pyridine synthesis
2synthesis methods
- Product Name:5-Ethyl-2-methoxy-pyridine
- CAS Number:847345-18-0
- Molecular formula:C8H11NO
- Molecular Weight:137.179
Yield:847345-18-0 55%
Reaction Conditions:
Stage #1: 2-methoxy-5-bromopyridinewith tert.-butyl lithium in tetrahydrofuran at -78; for 1 h;Inert atmosphere;
Stage #2: ethyl iodide in tetrahydrofuran at -78 - 25; for 8 h;Inert atmosphere;
References:
Suh, Sung-Eun;Chen, Si-Jie;Mandal, Mukunda;Guzei, Ilia A.;Cramer, Christopher J.;Stahl, Shannon S. [Journal of the American Chemical Society,2020,vol. 142,# 26,p. 11388 - 11393] Location in patent:supporting information