5-ETHYL-2-METHOXYACETOPHENONE synthesis
- Product Name:5-ETHYL-2-METHOXYACETOPHENONE
- CAS Number:29643-54-7
- Molecular formula:C11H14O2
- Molecular Weight:178.23
24539-92-2
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74-88-4
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29643-54-7
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Yield:29643-54-7 90%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 18 h;
Steps:
22 Intermediate 56: 1 -(5-ethyl-2-methoxyphenyl)ethanone
To a solution of 1 -(5-ethyl-2-hydroxyphenyl)ethanone (2.33 g, 14.19 mmol) in N,N- Dimethylformamide (15 mL) was added iodomethane (1 .325 mL, 21 .28 mmol). The reaction mixture was stirred at rt for 18 h. Water (10 mL) was added, and then the mixture was extracted with EtOAc (3x20 mL). The combined organic layers were washed with brine (10 mL). The organic layer was dried over Na2S04, and then concentrated under reduced pressure to give the product 1 -(5-ethyl-2-methoxyphenyl)ethanone (2.50 g, 12.81 mmol, 90 % yield) as a yellow oil. m/z: [M + H]+ Calcd for C11 H15O2 179.1 ; Found 179
References:
WO2019/63748,2019,A1 Location in patent:Page/Page column 258-259
3245-23-6
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29643-54-7
12 suppliers
$100.00/1g
24539-92-2
55 suppliers
$49.00/5g
77-78-1
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$22.00/25g
29643-54-7
12 suppliers
$100.00/1g