ChemicalBook CAS DataBase List 5-Fluoro-2-methylindole

5-Fluoro-2-methylindole synthesis

12synthesis methods

Product Name:5-Fluoro-2-methylindole
CAS Number:399-72-4
Molecular formula:C9H8FN
Molecular Weight:149.16

1-(5-fluoro-2-nitrophenyl) propane-2-one (0.5mmol, 99 mg), zinc powder (3.0mmol, 196 mg), and acetic acid (6.0mmol, 360 mg) was added to the reaction tube, followed by adding ethanol to 2 ml at 90 °C for 3h. After cooling to room temperature, the reaction system was added 20 ml water. 5-Fluoro-2-methylindole was obtained after purification.

823-85-8 Synthesis

823-85-8
365 suppliers
$5.00/5g

399-72-4
231 suppliers
$10.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1: aq. NaHCO₃ / CH₂Cl₂ / 3 h / 20 °C
2: ZnCl₂ / 140 °C

References:

McKew, John C.;Foley, Megan A.;Thakker, Paresh;Behnke, Mark L.;Lovering, Frank E.;Sum, Fuk-Wah;Tam, Steve;Wu, Kun;Shen, Marina W. H.;Zhang, Wen;Gonzalez, Mario;Liu, Shanghao;Mahadevan, Anu;Sard, Howard;Khor, Soo Peang;Clark, James D. [Journal of Medicinal Chemistry,2006,vol. 49,# 1,p. 135 - 158]

1266659-06-6 Synthesis