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5-formylthiophene-3-carbonitrile synthesis

3synthesis methods
3-Thiophenecarbonitrile, 5-(chloromethyl)-

80577-91-9
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80577-96-4 Synthesis
5-(hydroxymethyl)-3-Thiophenecarbonitrile

80577-96-4
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Yield:80577-96-4 4% ,51770-04-8 81%

Reaction Conditions:

with 2-lithio-2-nitropropane in dimethyl sulfoxide at 20; for 6.5 h;

References:

Newcombe, Peter J.;Norris, Robert K. [Australian Journal of Chemistry,1981,vol. 34,# 9,p. 1879 - 1886]