5-IODO-2-(TRIFLUOROMETHYL)BENZYL BROMIDE synthesis

Yield:1261682-47-6 36%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane at 60;

Steps:

164 Intermediate 164e: 2-(bromoniethyl)~4-iodo-l -(trifluoromethyl)benzene

To intermediate 164d (3.5 g, 12.24 mmol, 1.00 equiv) in CC1₄ (40 mL) at 60 °C was added benzoyl peroxide (1.7 g, 7.02 mmol, 0.57 equiv) followed by the batch-wise addition of NBS (2.37 g, 13.32 mmol, 1.09 equiv) and the reaction stirred at reflux overnight. The solids were filtered out and the filtrate concentrated to afford 1.6 g (36%) of intermediate 164e as a red oil.

References:

WO2013/96771,2013,A1 Location in patent:Page/Page column 222