5-IODO-PYRIDINE-3-CARBALDEHYDE synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 24 h / 120 °C / Schlenk technique
2.1: TurboGrignard / tetrahydrofuran / 3.5 h / -78 °C / Schlenk technique; Inert atmosphere
2.2: 12 h / -78 - 20 °C / Schlenk technique; Inert atmosphere

References:

Trobe, Melanie;Schreiner, Till;Vareka, Martin;Grimm, Sebastian;W?lfl, Bernhard;Breinbauer, Rolf [European Journal of Organic Chemistry,2022,vol. 2022,# 17,art. no. E202101280]