ChemicalBook CAS DataBase List 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE

5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE synthesis

11synthesis methods

Product Name:5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE
CAS Number:17288-40-3
Molecular formula:C8H8N2O
Molecular Weight:148.16

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
inquiry

17288-40-3
139 suppliers
$22.00/250mg

Yield: 95%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol;ethyl acetate under 3102.97 Torr; for 6 h;Parr apparatus;

Steps:

17.1
A suspension of (5-methoxy-3-nitro-pyridin-2-yl)-acetonitrile (Maybridge, 986 mg, 5.1 mmol) and Pd/C (10%, 986 mg) in EtOH/EtOAc (95/5, 50 mL) was shaken for 6 hours under H₂ (60 PSI) in Parr apparatus. The reaction mixture was then filtered through a celite pad, and the filter cake was washed with EtOAc (20 mL). The filtrate was concentrated, and the residue was dissolved in EtOAc (50 mL), washed with NaHCO₃ (saturated solution, 50 mL), dried over MgSO₄, filtered, concentrated, and purified via flash chromatography (hexane/EtOAc), affording 5-Methoxy-1H-pyrrolo[3,2-b]pyridine as a white solid (720 mg, 95% yield).

References:

Roche Palo Alto LLC US2007/123535, 2007, A1 Location in patent:Page/Page column 42