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5-Methoxybenzofuran-2-carbaldehyde synthesis

8synthesis methods
-

Yield:23145-19-9 70%

Reaction Conditions:

with acetic acid for 24 h;Reflux;

Steps:

General procedures for the synthesis of substitutedBenzo[b]furan-2-yl carboxaldehydes 4a-g: Method C

General procedure: A stirred solution of compounds 3 (0.1 mol) in 35 mL ofconcentrated acetic acid was refluxed for 24 h. After cooling,the solution was evaporated to dryness. The crude productwas distilled or recrystallized from an appropriate solvent.

References:

Boukharsa, Youness;Meddah, Bouchra;Tiendrebeogo, Ramata Yvette;Ibrahimi, Azeddine;Taoufik, Jamal;Cherrah, Yahia;Benomar, Ali;Faouzi, My El Abbes;Ansar, M'Hammed [Medicinal Chemistry Research,2016,vol. 25,# 3,p. 494 - 500]