ChemicalBook CAS DataBase List 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE

5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE synthesis

6synthesis methods

Product Name:5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
CAS Number:824-52-2
Molecular formula:C8H8N2
Molecular Weight:132.16

5-Methyl-3-((trimethylsilyl)ethynyl)pyridin-2-amine

500903-95-7
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$155.00/50mg

824-52-2
101 suppliers
$25.00/50mg

Yield:824-52-2 80%

Reaction Conditions:

with sodium hydride in 1-methyl-pyrrolidin-2-one;mineral oil at 100; for 0.166667 h;Cooling with ice;

Steps:

1.3 Step 3
Compound 2 (9.8 g, 48.0 mmol) and N-methylpyrrolidone (50 mL) were added to a three-necked flask;Sodium hydride (60%, 2.8 g, 59 mmol) was added to the ice bath,100 degrees Celsius for 10 minutes. Cool to room temperature,Saturated ammonium chloride solution (50 mL) was added and extracted with ethyl acetate (50 mL x 3); the organic phases were combined, washed with water (100 mL) and saturated brine (100 mL), dried over sodium sulphate and filtered. The filtrate was spin dried to give the crude product, which was recrystallized from ethyl acetate (10 mL) to give white solid, compound 3 (5.1 g, 38.6 mmol, 80%).

References:

Kanghua (Shanghai) Drug Discovery Co., Ltd.;Ma Jingxiang CN107056781, 2017, A Location in patent:Paragraph 0008

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