(5-(Methylsulfonyl)pyridin-2-yl)MethanaMine synthesis
- Product Name:(5-(Methylsulfonyl)pyridin-2-yl)MethanaMine
- CAS Number:848185-40-0
- Molecular formula:C7H10N2O2S
- Molecular Weight:186.23
848141-13-9
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848185-40-0
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Yield:848185-40-0 74.5%
Reaction Conditions:
with hydrogenchloride;palladium on activated charcoal;hydrogen in methanol;water at 20; for 0.5 h;
Steps:
12.2 Step 2: 5-(methylsulfonyl) 2-pyridinemethylamine
5-ethylsulfonyl-2-pyridinecarbonitrile (350 mg, 1.92 mmol), methanol (2 mL), concentrated hydrochloric acid (5 drops) and Pd/C (35 mg) were added to a 25 mL single-mouth bottle. The reaction mixture was stirred at room temperature for 30 minutes while introducing hydrogen gas, and filtered over celite, and the solvent was dried with rotation under vacuum to give the product (266 mg), with a yield of 74.5%. MS (ESI) m/z: 187.1 (MH+).
References:
EP3476829,2019,A1 Location in patent:Paragraph 0094
55338-73-3
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$26.00/100mg
848185-40-0
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