5-Phenyl-1,3,4-oxadiazole-2-methanol synthesis

6synthesis methods

Product Name:5-Phenyl-1,3,4-oxadiazole-2-methanol
CAS Number:54014-02-7
Molecular formula:C9H8N2O2
Molecular Weight:176.17

ETHYL 5-PHENYL-1,3,4-OXADIAZOLE-2-CARBOXYLATE

16691-25-1
59 suppliers
$28.28/250mgs:

54014-02-7
22 suppliers
$84.00/250mg

Yield:54014-02-7 80%

Reaction Conditions:

with sodium tetrahydroborate;calcium chloride in ethanol at 0 - 20; for 4 h;

Steps:

1.C Step C: Synthesis of (5-phenyl-1,3,4-oxadiazol-2-yl)methanol

Ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (2.71g, 12.42mmol)And calcium chloride (2.76g, 24.84mmol) suspended in ethanol (150mL),Add sodium borohydride (1.41g, 37.26mmol) at 0°C. After the addition,Move to room temperature and stir for 4 hours. Add water to quench the reaction (100mL),Ethyl acetate extraction (100mL x 2), the organic phase was washed with saturated brine (100mL x 3),It was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 1.75 g of white solid, yield: 80%.

References:

CN112979629,2021,A Location in patent:Paragraph 0161; 0167-0168

613-94-5 Synthesis