ChemicalBook CAS DataBase List Benzeneacetic acid, 4-chloro-a-methyl-, methyl ester

Benzeneacetic acid, 4-chloro-a-methyl-, methyl ester synthesis

11synthesis methods

Product Name:Benzeneacetic acid, 4-chloro-a-methyl-, methyl ester
CAS Number:50415-70-8
Molecular formula:C10H11ClO2
Molecular Weight:198.6461

67-56-1 Synthesis

67-56-1
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Benzeneacetic acid, 4-chloro-a-methyl-, methyl ester

50415-70-8
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Yield:50415-70-8 99%

Reaction Conditions:

with ion exchange resin IR-120(H+)Not specified; for 24 h;Heating / reflux;

Steps:

10.A

Preparative Example 10; Step A; A solution of commercially available 2-(4-chlorophenyl)-propionic acid (5.5 g) and ion exchange resin IR-120(H⁺) in dry MeOH (200 mL) was stirred under reflux for 24 h, filtered and the solvent was evaporated to dryness, cooled and the formed precipitate was filtered off to afford the title compound (5.84 g; 99%) as a colourless oil. [MH]⁺=199.

References:

US2008/21024,2008,A1 Location in patent:Page/Page column 79