(3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone synthesis

8synthesis methods

Product Name:(3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone
CAS Number:51073-13-3
Molecular formula:C18H14Br2O3
Molecular Weight:438.11

3562-84-3 Synthesis

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(3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

51073-13-3
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Yield:51073-13-3 100%

Reaction Conditions:

with potassium carbonate in acetone; for 16 h;Heating / reflux;

Steps:

8

Compound 2. A heterogeneous mixture of 1 (26.8 g, 60.0 mmol), K2CO3 (33.5 g, 240 mmol), and methyl iodide (12.9 g, 90.0 mmol) in acetone (200 mL) was heated to reflux for 16 hours. Ethyl acetate (300 mL) was added, and the mixture was extracted sequentially with water (200 mL), 2.5 M NaOH (2*100 mL), and brine (100 mL). The organic portion was dried over Na2SO4 and concentrated to give 26.3 g (100% yield) of the title compound as a white solid. <1>H NMR (CDCl3): [delta]1.36 (t, J=7.5 Hz, 3 H), 2.90 (q, J=7.5 Hz, 2 H), 3.98 (s, 3 H), 7.24 (app t, J=7.4 Hz, 1 H), 7.32 (app t, J=7.2 Hz, 1 H), 7.42 (d, J=7.2 Hz, 1 H), 7.50 (d, J=7.9 Hz, 1 H), 7.99 (s, 2 H). LRMS: ion 438 (M+).

References:

US2003/195247,2003,A1 Location in patent:Page/Page column 13

3562-84-3 Synthesis

3562-84-3
321 suppliers
$31.00/500mg