(3-BroMo-4-Methyl-phenyl)-carbaMic acid tert-butyl ester synthesis
- Product Name:(3-BroMo-4-Methyl-phenyl)-carbaMic acid tert-butyl ester
- CAS Number:515813-02-2
- Molecular formula:C12H16BrNO2
- Molecular Weight:286.16
7745-91-7
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515813-02-2
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Yield:515813-02-2 100%
Reaction Conditions:
with sodium hydroxide in water at 20; for 5 h;Heating / reflux;
Steps:
21.a
57.62 g (0.3 mol, 1 eq) of 3-bromo-4-methylaniline are added to a solution of 75.8 g (0.344 mol, 1.15 eq) of di-tert-butyl dicarbonate in 580 mL of 2N sodium hydroxide solution. The reaction medium is refluxed for one hour and stirred at room temperature for 4 hours. The reaction medium is filtered and the solid is washed with water until the filtrate is neutral, and then dried. 90.33 g of tert-butyl (3-bromo-4-methylphenyl)carbamate are obtained in solid form.Crude yield > 100%
References:
WO2006/18326,2006,A1 Location in patent:Page/Page column 46; 47
7745-91-7
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24424-99-5
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515813-02-2
27 suppliers
$45.00/100mg