![](/CAS/GIF/5174-90-3.gif)
2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:5174-90-3
- Molecular formula:C11H10N2O3
- Molecular Weight:218.21
![2-Amino-3-pyridinecarboxaldehyde](/CAS/GIF/7521-41-7.gif)
7521-41-7
331 suppliers
$6.00/1g
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
733 suppliers
$5.00/25g
![2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/5174-90-3.gif)
5174-90-3
52 suppliers
$24.00/250mg
Yield:5174-90-3 97%
Reaction Conditions:
with piperidine at 120;
Steps:
Ethyl2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (38).
A solution of commercially available 2-aminonicotinaldehyde(1.00g, 8.19 mmol), diethyl malonate (1.85 ml, 12.18mmol) and few drops of piperidine was stirred at 120°C for 20 hours. After themixture was cooled, the precipitate formed during the reaction was treated withethyl ether and then dried to give a yellow solid (1.74 g, 7.96 mmol, 97%yield). H-NMR (CDCl3): δ 1.42(t, 3H, J=7.2, CH3); 4.44(q, 2H, J= 7.2, CH2);7.27(dd, 1H, J=4.8 Hz, J=8 Hz, Ar); 8.04 (dd, 1H, J=1.6 Hz, J=8 Hz, Ar); 8.47(s, 1H, Ar); 8.90 (dd, 1H, J=1.6 Hz, J=4.8 Hz, Ar); 12.62 (s, 1H, NH) ppm.
References:
Sestito, Simona;Bacci, Andrea;Chiarugi, Sara;Runfola, Massimiliano;Gado, Francesca;Margheritis, Eleonora;Gul, Sheraz;Riveiro, Maria E.;Vazquez, Ramiro;Huguet, Samuel;Manera, Clementina;Rezai, Keyvan;Garau, Gianpiero;Rapposelli, Simona [European Journal of Medicinal Chemistry,2021,vol. 226,art. no. 113895] Location in patent:supporting information
![N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE](/CAS/GIF/86847-64-5.gif)
86847-64-5
84 suppliers
$61.00/250mg
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
733 suppliers
$5.00/25g
![2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/5174-90-3.gif)
5174-90-3
52 suppliers
$24.00/250mg
![2-Amino-3-pyridinecarboxaldehyde](/CAS/GIF/7521-41-7.gif)
7521-41-7
331 suppliers
$6.00/1g
![2,2-Dimethyl-1,3-dioxane-4,6-dione](/CAS/GIF/2033-24-1.gif)
2033-24-1
629 suppliers
$6.00/25g
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
705 suppliers
$10.00/50g
![2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/5174-90-3.gif)
5174-90-3
52 suppliers
$24.00/250mg
![Nicotinamide](/CAS/GIF/98-92-0.gif)
98-92-0
1162 suppliers
$5.00/5g
![2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/5174-90-3.gif)
5174-90-3
52 suppliers
$24.00/250mg
![Pyrido[2,3-d]pyrimidine, 2-(3-pyridinyl)-](/CAS/20180529/GIF/7521-27-9.gif)
7521-27-9
1 suppliers
inquiry
![2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/5174-90-3.gif)
5174-90-3
52 suppliers
$24.00/250mg