N-[[(4-Methylphenyl)sulfonyl]oxy]-ethanimidic acidethylester synthesis

Yield:52913-15-2 91%

Reaction Conditions:

with sodium hydroxide in ethanol at 15 - 25; for 2 h;

Steps:

7.1 (1) Preparation of compound ethyl O-p-toluenesulfonylacetohydroxamate

Add 500 mg of the reaction flask to ethyl acetohydroxamate (718, 0.511101, 1.069) and ethanol (284 mL, 4P) to form an ethanol solution of ethyl acetohydroxamate, and add hydrogen to the ethanol solution of sodium hydroxide (24 g, 0.6 mol, 1.2 eq), p-toluenesulfonyl chloride (114.39 g, 0.6 mol, 1.2 eq) was added dropwise, and the reaction was accelerated by magnetic stirring. The reaction temperature was controlled between 15-25 ° C and the addition was completed. The reaction mixture was allowed to react for 2 hours between 15 and 25 ° C. The reaction mixture was added to water (284 mL, 4P), and the precipitated solid was suction filtered, and the obtained cake was washed with ethanol, and the obtained solid was dried to obtain 134.8 g. ethyl O-p-toluenesulfonylacetylhydroxamate, yield 91%.

References:

CN108530315,2018,A Location in patent:Paragraph 0107-0109