1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE synthesis

10synthesis methods

Product Name:1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE
CAS Number:54001-07-9
Molecular formula:C12H10ClNOS
Molecular Weight:251.73

1694-29-7
100 suppliers
$40.00/10g

2521-24-6
166 suppliers
$15.00/1g

1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE

54001-07-9
20 suppliers
$181.00/500mg

Yield:54001-07-9 90%

Reaction Conditions:

in ethanol; for 8 h;

Steps:

4.1.1. General synthesis of 1-(4-methyl-2-(40-substitutedphenylthiazole-5-yl)ethane-1-one derivatives (methodA)

General procedure: According to the Hantzsch method, 3-chloro-2,4-pentandione isadded to the hot solution of aryl thioamide in absolute ethanol(Scheme 1) and boiled for 8 h. After being controlled with TLCwhere the reaction is completed, itwas left to cool, poured into coldwater and neutralized by sodium acetate solution. After the precipiationwas completed, it is taken and dried, crystallized fromethanol [40].

References:

Sahin, Zafer;Biltekin, Sevde Nur;Yurttas, Leyla;Berk, Barkin;?zhan, Ya?mur;Sipahi, Hande;Gao, Zhan-Guo;Jacobson, Kenneth A.;Demirayak, ?eref [European Journal of Medicinal Chemistry,2021,vol. 212,art. no. 113125]