4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis

7synthesis methods

Product Name:4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL
CAS Number:565174-22-3
Molecular formula:C8H7FN4S
Molecular Weight:210.23

5-(2-FLUORO-PHENYL)-[1,3,4]OXADIAZOLE-2-THIOL

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4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL

565174-22-3
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$45.00/50mg

Yield:565174-22-3 57%

Reaction Conditions:

with hydrazine hydrate in water; for 6 h;Reflux;

Steps:

4.B Step B: preparation of 4-amino-5 - (2-fluoro phenyl) - 4H-1, 2, 4-triazole-3-thiol

50mL round bottom flask was added 5 · 88g (30. 0mmol) 5- (2- fluorophenyl) -1,3,4_ oxadiazole-2-thiol, 18. 75g (30 (X Ommol) hydrazine hydrate ( 80%) and 20mL 7K, 6H heated to reflux with stirring. after cooling, diluted with 200mL water, adjusted with hydrochloric acid pH 1~2, filtration, and recrystallized from ethanol to give 3. 59g of brown solid in 57% yield.

References:

CN105330651,2016,A Location in patent:Paragraph 0076; 0077; 0078

446-24-2 Synthesis