3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one synthesis

5synthesis methods

Product Name:3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one
CAS Number:56676-49-4
Molecular formula:C10H9NO2S2
Molecular Weight:239.31

75-15-0
236 suppliers
$40.00/100g

3926-62-3 Synthesis

3926-62-3
261 suppliers
$19.73/250g

90-04-0
375 suppliers
$5.00/5G

3-(2-methoxyphenyl)-2-sulfanylidene-thiazolidin-4-one

56676-49-4
10 suppliers
$1000.00/5G

Yield:56676-49-4 63%

Reaction Conditions:

Stage #1: carbon disulfide;2-methoxy-phenylaminewith triethylamine in ethanol at 0; for 0.5 h;
Stage #2: sodium monochloroacetic acid in water at 20;
Stage #3: with hydrogenchloride in water; for 0.0833333 h;

Steps:

General procedure: Cyclohexanamine 6a (0.5g, 5mmol), and triethylamine (2.35g, 25mmol) were solved in ethanol (2ml), then carbon disulfide (0.76g, 10mmol)was dropped into mixture with stirring for 0.5h at 0 °C. The precipitate was filtered and washed by ether and solved in solution of sodium chloroacetate (0.64g, 5.5mmol) at RT overnight. 6M HCl (7ml)was added to reaction mixture and heated at 95 °C for 5min. The crude product was filtered and purified by recrystallization with chloroform to give the yellow solid as target compound

References:

Liang, Xiao;Fu, Huansheng;Xiao, Peng;Fang, Hao;Hou, Xuben [Bioorganic Chemistry,2020,vol. 103,art. no. 104124]

2365-48-2 Synthesis