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ChemicalBook CAS DataBase List Propanedioic acid, 2-(acetylaMino)-2-[(7-chloro-1H-indol-3-yl)Methyl]-, 1,3-diethyl ester

Propanedioic acid, 2-(acetylaMino)-2-[(7-chloro-1H-indol-3-yl)Methyl]-, 1,3-diethyl ester synthesis

1synthesis methods
1068-90-2 Synthesis
Diethyl acetamidomalonate

1068-90-2
540 suppliers
$5.00/25g

Propanedioic acid, 2-(acetylaMino)-2-[(7-chloro-1H-indol-3-yl)Methyl]-, 1,3-diethyl ester

582319-05-9
7 suppliers
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium methylate / benzene / 0.08 h
1.2: 20 °C / Cooling with ice
1.3: 60 h / 20 - 60 °C
2.1: sulfuric acid / water / 2 h / 55 - 60 °C

References:

Maitrani, Chandan;Phillips, Robert S. [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 15,p. 4670 - 4677]