6-[4-Aminophenyl]pyridazin-3(2H)-one synthesis
- Product Name:6-[4-Aminophenyl]pyridazin-3(2H)-one
- CAS Number:24912-35-4
- Molecular formula:C10H9N3O
- Molecular Weight:187.2
19064-67-6
191 suppliers
$10.00/1g
214360-73-3
328 suppliers
$8.00/1g
24912-35-4
17 suppliers
$45.00/10mg
Yield:24912-35-4 25%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in 1,4-dioxane;water at 160; for 1.5 h;
Steps:
153.153-2 Step 153- 2: Preparation of 6-(4-aminophenyl) pyridazine-3(2H)-one
6-chloropyridazine-3(2H)-one(100 mg, 0.77 mmol) And 4-aminophenylboronic acid pinacol ester (168 mg, 0.77 mmol)Was dissolved in 1,4-dioxane solution, and then Pd(PPh3)4 (89 mg, 0.08 mmol)And potassium carbonate aqueous solution (423 mg, 3.06 mmol)Was added.The reaction mixture was stirred in a microwave at 160° C. for 1.5 hours.When the reaction was completed, extraction was performed using distilled water and ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the concentrate was purified by column chromatography to obtain the title compound.36 mg (25% yield) was obtained.
References:
KR2020/76655,2020,A Location in patent:Paragraph 1866; 1872-1874
105537-49-3
4 suppliers
inquiry
24912-35-4
17 suppliers
$45.00/10mg
100-19-6
303 suppliers
$5.00/5g
24912-35-4
17 suppliers
$45.00/10mg