6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE synthesis
- Product Name:6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE
- CAS Number:28566-14-5
- Molecular formula:C8H7NO
- Molecular Weight:133.15
![Cyclopenta[b]pyridine](/CAS/GIF/533-37-9.gif)
533-37-9
326 suppliers
$6.00/5g
28566-14-5
150 suppliers
$31.00/100mg
Yield:28566-14-5 91%
Reaction Conditions:
with tert.-butylhydroperoxide;manganese(II) triflate in water at 20; for 24 h;
Steps:
1 Example 1 Synthesis of 6,7-dihydro-5H-cyclopenta [b] pyridin-5-one
A solution of 0.883 mg of Mn (OTf) 2 (0.5 mol%), 60 mg of 2,3-cyclopentenopyridine, 0.35 g of 65% aqueous TBHP and 2.5 ml of water was added successively to a 25 mL round bottom flask, in the air at room temperature for 24 hours, the reaction solution was extracted with 3 x 5 mL of ethyl acetate, the ethyl acetate layer was collected, dried over anhydrous sodium sulfate, filtered and the ethyl acetate was distilled off, using petroleum ether and ethyl acetate in a volume ratio of 5: 1 as eluent, the product of 6,7-dihydro-5H-cyclopenta [b] pyridin-5-one 60.5 mg was obtained as a pale yellow solid in a yield of 91% by silica gel column chromatography.
References:
Dalian Institute of Chemical Physics, Chinese Academy of Sciences;Gao, Shuang;Ren, Lanhui;Wang, Lianyue;Lv, Ying;Zhang, Yi CN105669548, 2016, A Location in patent:Paragraph 0027; 0028
122-31-6
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$21.00/25mL
3859-41-4
290 suppliers
$6.00/1g
28566-14-5
150 suppliers
$31.00/100mg
624-67-9
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$120.00/500mg
28566-12-3
25 suppliers
$45.00/10mg
28566-14-5
150 suppliers
$31.00/100mg