6-aMino-2-Methylpyridazin-3(2H)-one synthesis
- Product Name:6-aMino-2-Methylpyridazin-3(2H)-one
- CAS Number:13506-28-0
- Molecular formula:C5H7N3O
- Molecular Weight:125.13
10071-38-2
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Yield:13506-28-0 52%
Reaction Conditions:
with ammonia at 150; for 60 h;
Steps:
6.a
3 g (20.7 mmoles) of this solid are placed in a stainless steel reactor in 60 mL of 32 % ammonia. The reaction medium is agitated for 6Oh at 1500C then concentrated to dryness. The residue obtained is purified twice by silica gel flash chromatography (CH2Cl2-MeOH, gradient 100:0 to 90:10 in 40 min) . 1.35 g of intermediate 6a are thus obtained in the form of a yellow solid (yield 52%) . TLC silica gel 60 F 254 Merck, CH2Cl2-MeOH: 90:10, Rf=O.31.
References:
WO2011/15629,2011,A1 Location in patent:Page/Page column 69
57041-95-9
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74-88-4
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