6-Bromo-2,3-dichlorobenzaldehyde synthesis

Yield:945999-86-0 98%

Reaction Conditions:

with N-Bromosuccinimide;4-chloro-2-(trifluoromethyl)aniline;palladium diacetate in 1,2-dichloro-ethane;trifluoroacetic acid at 60; for 24 h;

Steps:

1.2 General procedure for the synthesis of 3a-3w

General procedure: Compound 1 (0.4 mol), N-bromosuccinimide (NBS) (0.48 mol, 85.4 mg), and Pd(OAc)2(10 mol%, 8.9 mg), 2-Amino-5-chlorobenzotrifluoride (20 mol%, 15.6 mg) were mixed withDCE (2.5 mL) and TFA (0.5 mL) solvent. The reaction mixture was stirred 24 h at 60 °C. Aftercompletion of the reaction, the solution was concentrated in vacuo and purified by columnchromatography on silica gel using PE/DCM/EtOAc as eluent to give the desired product.

References:

Yong, Qiyun;Sun, Bing;Zhang, Fang-Lin [Tetrahedron Letters,2019,vol. 60,# 46,art. no. 151263] Location in patent:supporting information