ChemicalBook CAS DataBase List 6-BROMO-2-METHOXY-PYRIDIN-3-YLAMINE

6-BROMO-2-METHOXY-PYRIDIN-3-YLAMINE synthesis

9synthesis methods

Product Name:6-BROMO-2-METHOXY-PYRIDIN-3-YLAMINE
CAS Number:89466-18-2
Molecular formula:C6H7BrN2O
Molecular Weight:203.04

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Yield:89466-18-2 100%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water at 80; for 1 h;Inert atmosphere;

Steps:

1.2 Step 2: Synthesis of 6-bromo-2-methoxypyridine-3-amine

At room temperature, 6-bromo-2-methoxy-3-nitropyridine (9.50 g, 38.62 mmol),Iron powder (11.50g, 193.11mmol), ammonium chloride (10.80g, 193.11mmol) and ethanol (190ml),Water (95 ml) was protected by nitrogen, the temperature was raised to 80 ° C, and the reaction was terminated in 1 h.The reaction solution was filtered with celite, the filtrate was concentrated, water (950 ml) was added, EA (380 ml x 2) was extracted, and the organic phases were combined.Saturated saline (200 ml) was added for washing, and then concentrated to obtain 8.28 g of a black oily liquid with a yield of 100%.

References:

CN110642838,2020,A Location in patent:Paragraph 0113; 0119-0121