![](/CAS/GIF/147497-32-3.gif)
6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE synthesis
- Product Name:6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- CAS Number:147497-32-3
- Molecular formula:C9H8BrNO
- Molecular Weight:226.07
![5-Bromo-1-indanone](/CAS/GIF/34598-49-7.gif)
34598-49-7
366 suppliers
$14.00/5g
![6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/147497-32-3.gif)
147497-32-3
146 suppliers
$14.00/100mg
Yield:147497-32-3 66%
Reaction Conditions:
with sodium azide;toluene-4-sulfonic acid in dichloromethane at -5 - 0;Inert atmosphere;
Steps:
1.I-1 1-1. 6- romo-3,4-dihydroisoqnmolm-l(2H)-one
00297] Under N2 atmosphere, to a solution of 5-bromo-2,3-dihydro-lH-inden-l-one (10 g, 47.39 mmol) and methanes ulfonic acid (45.5 g, 473 93mmol) in DCM (75 mL) was added NaNi (6.2 g, 94.79 mmol) slowly in portions at ~5~0 °C with stirring. After the addition was completed, the mixture was kept at 0°C for 3 hours. The reaction mixture was adjusted to pH=10 with 20% NaOH aqueous solution and extracted with DCM. The combined organic layers w-ere -washed with water three times and then with brine, dried over MgSOy filtered and concentrated. The residue was purified by flash column chromatography (0% to 70% EtOAc in hexanes) to afford 6.9 g product in 66% yield. LCMS (ESI) m/z 226.08 [(M+H)+; calcd for CsHsBrNOL 226.07]
References:
WO2019/118728,2019,A1 Location in patent:Paragraph 00297
![5-Bromo-1-indanone](/CAS/GIF/34598-49-7.gif)
34598-49-7
366 suppliers
$14.00/5g
![6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/147497-32-3.gif)
147497-32-3
146 suppliers
$14.00/100mg
![6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE](/CAS/GIF/3279-90-1.gif)
3279-90-1
150 suppliers
$10.00/1g
![3-BROMOPHENETHYLAMINE](/CAS/GIF/58971-11-2.gif)
58971-11-2
176 suppliers
$10.00/1g
![6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/147497-32-3.gif)
147497-32-3
146 suppliers
$14.00/100mg
![Methanesulfonic acid](/CAS/GIF/75-75-2.gif)
75-75-2
611 suppliers
$10.00/5g
![5-Bromo-1-indanone](/CAS/GIF/34598-49-7.gif)
34598-49-7
366 suppliers
$14.00/5g
![6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/147497-32-3.gif)
147497-32-3
146 suppliers
$14.00/100mg
![Bromobenzene](/CAS/GIF/108-86-1.gif)
108-86-1
496 suppliers
$10.00/5g
![6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/147497-32-3.gif)
147497-32-3
146 suppliers
$14.00/100mg