6-Bromo-3-isopropoxy-2-methylpyridine synthesis

3synthesis methods

Product Name:6-Bromo-3-isopropoxy-2-methylpyridine
CAS Number:1392466-94-2
Molecular formula:C9H12BrNO
Molecular Weight:230.1

118399-86-3
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Yield:1392466-94-2 85%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 100;

Steps:

Step 3: 6-Bromo-3-isopropoxy-2-methylpyridine[00397] 6-Bromo-2-methylpyridin-3-ol (10.5 g, 55.9 mmol) was dissolved in DMF (100 mL). K₂C0₃ (19.3 g, 139.6 mmol) and 2-bromopropane (13.1 ml, 139.6 mmol) were added to the solution and the mixture was heated at 100 °C overnight. The mixture was poured into a mixture of water and EtOAc (200 mL). The layers were separated and the aqueous layer was extracted with EtOAc (2x). The combined organic layers were dried(Na₂S0₄) and concentrated. The crude oil was purified by column chromatography (0-20% ethyl acetate/heptanes) to give 6-bromo-3-isopropoxy-2-methylpyridine (10.9 g, 85) as a yellow oil. 1H- MR (300 MHz, CDC1₃) 1.42 (d, 6H), 2.48 (s, 3H), 4.65 (m, 1H), 7.20 (d, 1H), 8.04 (d, 1H).

References:

WO2012/112743,2012,A1 Location in patent:Page/Page column 154

1121-25-1 Synthesis

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References

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References