6-BROMO-8-FLUORO-2-NAPHTHOL synthesis
- Product Name:6-BROMO-8-FLUORO-2-NAPHTHOL
- CAS Number:82995-06-0
- Molecular formula:C10H6BrFO
- Molecular Weight:241.06
118-46-7
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82995-06-0
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Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: methanol / 1.5 h / Heating
2.1: K2CO3 / acetone / 6 h / Heating
3.1: aq. HCl / 5 h / Heating
4.1: aq. HCl; NaNO2 / 0.5 h / 10 °C
4.2: aq. HBF4
4.3: xylene / 1 h / Heating
5.1: 3.99 g / BBr3 / CH2Cl2 / 0 - 20 °C
6.1: 62 percent / Br2; acetic acid / 1 h / 100 °C
7.1: 41 percent / SnCl2; aq. HCl; acetic acid / 1 h / 100 °C
References:
Mewshaw, Richard E.;Edsall Jr., Richard J.;Yang, Cuijian;Manas, Eric S.;Xu, Zhang B.;Henderson, Ruth A.;Keith Jr., James C.;Harris, Heather A. [Journal of Medicinal Chemistry,2005,vol. 48,# 12,p. 3953 - 3979]
550998-28-2
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82995-06-0
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13791-03-2
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93189-18-5
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5302-79-4
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82995-06-0
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