![](/CAS/GIF/57339-57-8.gif)
6-bromoquinolin-8-amine synthesis
- Product Name:6-bromoquinolin-8-amine
- CAS Number:57339-57-8
- Molecular formula:C9H7BrN2
- Molecular Weight:223.07
![6-bromo-8-nitroquinoline](/CAS/GIF/68527-67-3.gif)
68527-67-3
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![6-bromoquinolin-8-amine](/CAS/GIF/57339-57-8.gif)
57339-57-8
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$184.00/250mg
Yield:57339-57-8 91%
Reaction Conditions:
with iron;acetic acid in ethanol;water; for 3 h;Heating / reflux;
Steps:
49 INTERMEDIATE 49 6-Bromo-8-amino-quinoline
To a solution of 6-bromo-8-nitro-quinoline (4 g, 1.58 mmol) in EtOH/HOAc/H2O (50 mL/50mL/25mL) was added iron metal (3.18 g, 5.69 mmol). The resulting solution was heated at reflux for 3 hours. The cooled reaction mixture was neutralized with 2.5 N NaOH, filtered through celite to remove iron solids and washed with EtOAc. The eluent was extracted into EtOAc (3 x 200 mL), combined, dried over Na2SO4 and concentrated. The resulting oil was purified by column chromatography (40% EtOAc/hexanes) affording 3.19 g (91%) of a yellow solid: mp 142-145°C.
References:
EP1147083,2004,B1 Location in patent:Page 46
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875-51-4
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$5.00/1g
![6-bromoquinolin-8-amine](/CAS/GIF/57339-57-8.gif)
57339-57-8
45 suppliers
$184.00/250mg
![2-Nitroaniline](/CAS/GIF/88-74-4.gif)
88-74-4
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$10.00/1g
![6-bromoquinolin-8-amine](/CAS/GIF/57339-57-8.gif)
57339-57-8
45 suppliers
$184.00/250mg
![6-Bromoquinoline](/CAS/GIF/5332-25-2.gif)
5332-25-2
416 suppliers
$6.00/5g
![6-bromoquinolin-8-amine](/CAS/GIF/57339-57-8.gif)
57339-57-8
45 suppliers
$184.00/250mg